ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity of this particular neoplasm, it is not always possible to predict the presence of this tumor preoperatively on the basis of clinical and sonographic findings. Histopathological and immunohistochemical (IHC) examinations confirm the diagnosis. Herein, the clinical findings and histopathological features of SST are described in a 24-year-old female.

HBME-l is an antimesothelial monoclonal antibody that recognizes an unknown antigen on microvilli of mesothelial cells. The antibody is only relatively specific for mesothelium and is used in the differential diagnosis of mesothelioma and adenocarcinoma within the context of an appropriate immuno-histochemical panel. HBME-l has also been reported to strongly and uniformly stain papillary and follicular carcinoma of the thyroid while Benign disorders have been usually negative. We studied the immunoreactivity of HBME-l in 90 cases of Benign and malignant thyroid lesions. We found strong positive staining in the majority of papillary carcinomas (28/31), in some of follicular carcinomas (4/6), and in a few follicular adenomas (2/17). Negative staining was found in oxyphilic cell adenoma (0/4), nodular goiter (0/13) and undifferentiated carcinoma. The results suggest that monoclonal antibody HBME-l is useful in differentiating papillary and follicular carcinoma of the thyroid from Benign lesions, especially in more differentiated lesions. Strong and generalized immunoreactivity for HBME-l in a follicular lesion should raise the suspicion of malignancy, but negative staining specially in poorly differentiated lesion does not rule out malignancy.

Background and Objective: ovarian tumors are among the most frequent pathologic conditions in gynecologic practice and a frequent cause of hospitalization and surgery. The aim of this study was to determine histologic distribution of Benign operated masses especially functional ovarian cysts. Material and Methods: Benign ovarian files of operated patients (2961 cases) in 20 tertiary and secondary hospitals were reviewed regarding age and histopathology from 1998- 2005. Analysis was done by SPSS software (version 13).Results: The most common Benign histologies in order of frequency were functional cyst (57%), serous cystadenoma (13%), dermoid cyst (10%), mucinous cystadenoma (7%) and endometrioma (6%).Conclusion: Functional cysts were the most common Benign ovarian cyst. Nearly high distribution of functional cysts in the present study may be an index of need to management improvement and less surgical decisions in ovarian tumors.

Objective: ovarian tumors represent about 1.5% of all tumors in childhood and adolescence and about 95% of all gynaecologic tumors. This paper analyzes 79 cases of ovarian tumor in children and adolescents.Material & Method: In this retrospective study 79 cases with ovarian tumor in children and adolescents treated in Mashhad Imam Reza Hospital from March 1981 to March 2001 were evaluated. Result: All cases were under 20 years with median age 17.4 years, and the youngest was 13 months. The tumors were classified according to WHO classification. Of 79 cases 61 (77.3%) were Benign and 18(22.7%)] were malignant. Forty (50.2%) were considered to be of germ cell, 34] (43.1%)] celomic epithelial, 3 (3.7%) sex cord-stromal origin, 1(1.2%) Burkit lymphoma and 1] (1.2%) mixed epithelial and germ cell origin. Forty cases had germ cell tumor: there were 26 teratoma, 9 dysgerminoma, 3 yolk sac tumor, 2 malgniant mixed germ cell tumor. Thirty-four cases had epithelial neoplasm, 25 Benign serous nepolasm and 9 mucinous tumor. Two cases of mucinous neoplasm were borderline and malignant. Three cases had sex cord stromal tumor: 1 setroli -lydig, 1 juveinal granulosa cell tumor, 1 fibrotechoma. In 76 cases were tumors unilateral and 3 cases (2 patients with dysgerminom and 1patient with Burkit lymphoma)] were bilateral. Tumoral torsion accounted for 11.3%of diagnosis, Conculsion: cell tumors are the most common ovarian neoplasm seen in the pediatric and adolesent age group.] Epithelial and sex cord stromal tumors are less common.]These neoplasms are Benign, borderline or malignant.] It is very important to sis exactly and to assess suitable treatment in this age group to protect fertility.

Benign mesenchymoma is a soft tissue neoplasm that contains 2 or more mature mesenchymal tissues in addition to fibrous tissue. A rare case of gingival Benign mesenchymoma in a 53- year- old man is presented and the clinicopathologic characteristics of this uncommon tumor in the head and neck region is reviewed and discussed.

ovarian epithelial type carcinomas of testis are an extremely rare group of tumors, a few cases of which having been reported. We present the case of a 67-year-old man, presented with testicular mass and inflation, who underwent radical orchiectomy and pathological and immunohistochemical assessments revealed serous papillary carcinoma of ovarian epithelial type tumor of testis.